Boronic acid-rich dendrimer for efficient intracellular peptide delivery
نویسندگان
چکیده
منابع مشابه
Boronic Acid for the Traceless Delivery of Proteins into Cells.
The use of exogenous proteins as intracellular probes and therapeutic agents is in its infancy. A major hurdle has been the delivery of native proteins to an intracellular site of action. Herein, we report on a compact delivery vehicle that employs the intrinsic affinity of boronic acids for the carbohydrates that coat the surface of mammalian cells. In the vehicle, benzoxaborole is linked to p...
متن کاملSynthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides
Arginine-rich cell-penetrating peptides have found excellent utility in cell and in vivo models for enhancement of delivery of attached charge-neutral PNA or PMO oligonucleotides. We report the synthesis of dendrimeric peptides containing 2- or 4-branched arms each having one or more R-Ahx-R motifs and their disulfide conjugation to a PNA705 splice-redirecting oligonucleotide. Conjugates were a...
متن کاملCellular internalization of fluorescent proteins via arginine-rich intracellular delivery peptide in plant cells.
The protein delivery across cellular membranes or compartments is limited by low biomembrane permeability because of the hydrophobic characteristics of cell membranes. Usually the delivery processes utilize passive protein channels or active transporters to overcome the membrane impediment. In this report, we demonstrate that arginine-rich intracellular delivery (AID) peptide is capable of effi...
متن کاملIntracellular delivery of protein and peptide therapeutics.
Many proteins and peptides are used as highly specific and effective therapeutic agents. Their use is, however, complicated by their instability and side effects. Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes cur...
متن کاملBoronic acid and boronic ester containing polyoxometalates.
Three organoboron functionalized polyoxometalates have been synthesized using Schiff base chemistry including a boronic acid, its methyl ester and its trimethylene glycol ester. The compounds have been characterized in the solid state by single crystal diffraction (XRD), FT-IR and elemental analysis and in solution using 1H NMR spectroscopy.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science China Materials
سال: 2019
ISSN: 2095-8226,2199-4501
DOI: 10.1007/s40843-019-1213-2